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  1. Long-term atmospheric exposure to PCB153 and breast cancer risk in a case-control study nested in the French E3N cohort from 1990 to 2011 ; : Environ Res
    Autor*in: Deygas, Floriane ; Amadou, Amina ; Coudon, Thomas ; Grassot, Lény ; Couvidat, Florian ; Bessagnet, Bertrand ; Faure, Élodie ; Salizzoni, Pietro ; Gulliver, John ; Caudeville, Julien ; Severi, Gianluca ; Romana Mancini, Francesca ; Leffondré, Karen ; Fervers, Béatrice ; Praud, Delphine
    Erschienen: 2021
    Verlag:  HAL CCSD ; Elsevier

    International audience ; BACKGROUND: Although the genetic and hormonal risk factors of breast cancer are well identified, they cannot fully explain the occurrence of all cases. Epidemiological and experimental studies have suggested that exposure to... mehr

     

    International audience ; BACKGROUND: Although the genetic and hormonal risk factors of breast cancer are well identified, they cannot fully explain the occurrence of all cases. Epidemiological and experimental studies have suggested that exposure to environmental pollutants, especially those with potential estrogenic properties, as polychlorinated biphenyls (PCBs) may have a role in breast cancer development. Being the most abundantly detected in human tissues and in the environment, congener 153 (PCB153) is widely used in epidemiological studies as indicator for total PCBs exposure. OBJECTIVES: We aimed to estimate the association between cumulative atmospheric exposure to PCB153 and breast cancer risk. METHODS: We conducted a case-control study of 5,222 cases and 5,222 matched controls nested within the French E3N cohort from 1990 to 2011. Annual atmospheric PCB153 concentrations were simulated with the deterministic chemistry-transport model (CHIMERE) and were assigned to women using their geocoded residential history. Their cumulative PCB153 exposure was calculated for each woman from their cohort inclusion to their index date. Breast cancer odds ratios (ORs) associated with cumulative PCB153 exposure and their 95% confidence intervals (95% CI) were estimated using multivariate conditional logistic regression models. RESULTS: Overall, our results showed a statistically significant linear increase in breast cancer risk related to cumulative atmospheric exposure to PCB153 as a continuous variable (adjusted OR=1.19; 95% CI: 1.08-1.31 for an increment of one standard deviation among controls (55 pg/m(3))). Among women who became postmenopausal during follow-up, the association remained statistically significant (adjusted OR=1.23; 95% CI: 1.09-1.39). In analyses by hormone receptors status, the positive association remained significant only for ER-positive breast cancer (adjusted OR=1.18; 95% CI: 1.05-1.33). DISCUSSION: This study is the first to have estimated the impact of atmospheric exposure to PCB153 on ...

     
    Export in Literaturverwaltung
    Quelle: BASE Fachausschnitt Germanistik
    Sprache: Englisch
    Medientyp: Konferenzveröffentlichung
    Format: Online
    Übergeordneter Titel: 33. Annual Conference of the International Society for Environmental Epidemiology (ISEE 2021): Promoting Environmental Health and Equity in a Shifting Climate ; https://hal-ineris.archives-ouvertes.fr/ineris-03514422 ; 33. Annual Conference of the International Society for Environmental Epidemiology (ISEE 2021): Promoting Environmental Health and Equity in a Shifting Climate, International Society for Environmental Epidemiology, Aug 2021, New York, United States. pp.110743, ⟨10.1016/j.envres.2021.110743⟩
    Schlagworte: Polychlorinated biphenyls; Air pollution; Breast cancer; Residential history; Nested case-control; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [SDV]Life Sciences [q-bio]; [SDV.EE]Life Sciences [q-bio]/Ecology; environment
    Lizenz:

    creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess
  2. Risk of breast cancer associated with long-term exposure to Benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study
    Autor*in: Amadou, Amina ; Praud, Delphine ; Coudon, Thomas ; Deygas, Floriane ; Grassot, Lény ; Faure, Élodie ; Couvidat, Florian ; Caudeville, Julien ; Bessagnet, Bertrand ; Salizzoni, Pietro ; Gulliver, John ; Leffondré, Karen ; Severi, Gianluca ; Romana Mancini, Francesca ; Fervers, Béatrice
    Erschienen: 2021
    Verlag:  HAL CCSD

    International audience ; BACKGROUND AND AIM: Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive toxicant, however epidemiological evidence of... mehr

     

    International audience ; BACKGROUND AND AIM: Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive toxicant, however epidemiological evidence of its long-term effect on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according to menopausal status and molecular subtypes (estrogen receptor negative/positive (ER-/ER+) and progesterone receptor negative/positive (PR-/PR+)), stage and grade of differentiation of BC in the French E3N cohort study. METHODS: Within a nested case-control study of 5,222 incident BC cases and 5,222 matched controls, annual BaP exposure was estimated using a chemistry-transport model (CHIMERE) and was assigned to the geocoded residential addresses of participants for each year during the 1990-2011 follow-up period. Multivariable conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS:Overall, cumulative airborne BaP exposure was significantly associated with the overall risk of BC, for each 1 interquartile range (IQR) increase in the concentration levels of BaP (1.42 ng/m3), the OR = 1.15 (95%CI: 1.04-1.27). However, by menopausal status, the significant positive association remained only in women who underwent menopausal transition (i.e. premenopausal women at inclusion who became postmenopausal at diagnosis), OR per 1 IQR = 1.20; 95%CI: 1.03-1.40. By hormone receptor status, positive associations were observed for ER+, PR+ and ER+PR+ BC, with ORs = 1.17 (95%CI: 1.04-1.32), 1.16 (95%CI: 1.01-1.33), and 1.17 (95%CI: 1.01-1.36) per 1 IQR, respectively. There was also a borderline positive association between BaP and grade 3 BC (OR per 1 IQR = 1.15(95%CI: 0.99-1.34). CONCLUSIONS:We provide evidence of increased risk of BC associated with cumulative BaP exposure, which varied according to menopausal status, hormone receptor status, and grade of ...

     
    Export in Literaturverwaltung
    Quelle: BASE Fachausschnitt Germanistik
    Sprache: Englisch
    Medientyp: Konferenzveröffentlichung
    Format: Online
    Übergeordneter Titel: 33. Annual Conference of the International Society for Environmental Epidemiology (ISEE 2021): Promoting Environmental Health and Equity in a Shifting Climate ; https://hal-ineris.archives-ouvertes.fr/ineris-03514659 ; 33. Annual Conference of the International Society for Environmental Epidemiology (ISEE 2021): Promoting Environmental Health and Equity in a Shifting Climate, International Society for Environmental Epidemiology, Aug 2021, New York, United States. ⟨10.1016/j.envint.2021.106399⟩
    Schlagworte: airborne benzo[a]pyrene; breast cancer; residential history; menopausal transition; hormone receptor status; differentiation grade; [SDE]Environmental Sciences; [SDV]Life Sciences [q-bio]; [SDV.EE]Life Sciences [q-bio]/Ecology; environment; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
    Lizenz:

    creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
  3. Adaptation de la faune souterraine aux basses températures : mécanismes et enjeux écologiques
    Autor*in: Issartel, Julien
    Erschienen: 2007
    Verlag:  HAL CCSD

    Subterranean fauna adaptations to low temperatures: mechanisms and ecological aspects. Subterranean ecosystems are generally characterised by reduced yearly thermal variations (± 1°C along the year). Thus, hypogean organisms should present stenotherm... mehr

     

    Subterranean fauna adaptations to low temperatures: mechanisms and ecological aspects. Subterranean ecosystems are generally characterised by reduced yearly thermal variations (± 1°C along the year). Thus, hypogean organisms should present stenotherm profiles (reduced tolerance to thermal variations), as they never endure variation of the temperature during their life cycle. Yet, several biospeologists observed a surprising survival to negatives temperatures in the subterranean crustacean Niphargus rhenorhodanensis. In order to determine the N. rhenorhodanensis thermobiological scale as well as the adaptive mechanisms allowing its cold tolerance, we measured its responses to low temperatures and we compared them to those of another hypogean crustacean (Niphargus virei) and to those of a morphologically close surface-dwelling crustacean (Gammarus fossarum). N. rhenorhodanensis showed larger survival times at -2°C than the two other organisms. Performance experiments (oxygen consumption, locomotory and ventilatory activities) when exposed to different temperatures (from -2 to 28°C) pointed out that N. rhenorhodanensis exhibited a eurytherm profile (maximising its performance on a broader range of temperature). Finally, during cold exposure, N. rhenorhodanensis shows i) a cryoprotectant (trehalose, free amino acid) body accumulations, ii) a decrease in free water body content (water that is able to participate in ice formation), and iii) a inoculative freezing tolerance. At the opposite, inoculative freezing is lethal in the two other organisms, with limited cryoprotectant body content increases, and no variation in free water body contents. With the support of recent phylogeographical studies, we hypothesise that cold hardiness pointed out in N. rhenorhodanensis might result form its life history during quaternary glaciations. ; De par leur structure, les écosystèmes souterrains présentent des variations thermiques extrêmement faibles (± 1°C sur l'année). De ce fait, les animaux hypogés devraient présenter des ...

     
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      BibTeX-Format
    Quelle: BASE Fachausschnitt Germanistik
    Sprache: Französisch
    Medientyp: Dissertation
    Format: Online
    Übergeordneter Titel: https://theses.hal.science/tel-00173375 ; Ecologie, Environnement. Université Claude Bernard - Lyon I, 2007. Français. ⟨NNT : ⟩
    Schlagworte: ecophysiology; response to cold; ecophysiologie; adaptation au froid; [SDV.EE]Life Sciences [q-bio]/Ecology; environment
    Lizenz:

    info:eu-repo/semantics/OpenAccess
  4. Askr and Embla: The Creation of Man from Trees
    Autor*in: Walther, Sabine Heidi
    Erschienen: 2023
    Verlag:  Brepols

    Sabine Heidi Walther discusses possible origins and medieval interpretations of the narrative of how humans are created from trees, as described in the eddicpoem Vǫluspá. Walther argues that this narrative should not necessarily be seen... mehr

     

    Sabine Heidi Walther discusses possible origins and medieval interpretations of the narrative of how humans are created from trees, as described in the eddicpoem Vǫluspá. Walther argues that this narrative should not necessarily be seen astransmitting part of a pre-Christian Nordic (or even Indo-European) cosmogony,since it also fits well with medieval Christian use of tree imagery. She points outparallels to the idea of the human being as arbor inversa (inverted tree) in medieval learned literature, as well as to Origo crucis (Legend of the Cross), both of which wereknown in medieval Iceland. Although not constituting direct models for Vǫluspá, such texts and motifs would, according to Walther, have allowed an interpretation ofthe first humans Askr and Embla as Adam and Eve, as well as of them symbolizing the Holy Cross and Christ. Walther concludes that an interpretatio Christiana of thenarrative of humans’ creation from trees does not make it more anthropocentricthan if it is understood as a pagan ‘environmental’ myth, but that it puts it into aneschatological perspective.

     
    Export in Literaturverwaltung   RIS-Format
      BibTeX-Format
    Quelle: BASE Fachausschnitt Germanistik
    Sprache: Englisch
    Medientyp: Aufsatz aus einem Sammelband
    Format: Online
    DDC Klassifikation: Andere germanische Sprachen (439)
    Schlagworte: ecocriticism; old norse studies; environment
    Lizenz:

    Namensnennung-Nicht-kommerziell 4.0 International ; creativecommons.org/licenses/by-nc/4.0/ ; openAccess